Scheda di dettaglio

 

TCR/MHCII-collagene interaction inhibitors useful for the treatment of rheumatoid arthritis

The T cells specific to human collagen type II, one of the possible autoantigens, have a crucial role in the development 5 of rheumatoid arthritis in the context of HLA-DR4. The protein-protein interactions between the T cell receptor (TCR) and the type II collagen linked to the allele MHC of class II HLA-DR4 may thus represent the target for the development of new drugs against rheumatoid arthritis. Using computational virtual screening techniques, 10 families of pharmacologically active molecules have been identified that interfere with the TCR/collagen II-MHCII interaction. The compounds identified here open up new possibilities in the treatment of rheumatoid arthritis.

 
 


Inventori

  • DE ROSA MARIA CRISTINA
  • Ria Francesco
  • Giardina Bruno
  • Ferraccioli Gianfranco
  • Pirolli Davide
  • Nicol˛ Chiara
 
 


TitolaritÀ

  • Consiglio Nazionale delle Ricerche
  • UniversitÓ Cattolica del Sacro Cuore
 
 


Classificazioni

  • preparazioni per uso medico, dentale o per l'igiene personale
  • composti eterociclici
 
 


Settore Tecnologico

  • ricerca medica, diagnosi e cure
 
 


Keyword

 
 


Vantaggi

 
 


Applicazioni

 

fonte dati: "Gestione Trovati" | brevetti.cnr.it | www.cnr.it | Consiglio Nazionale delle Ricerche | P.le Aldo Moro, 7 | 00185 Roma